Police are calling an early morning shooting in Invercargill, a targeted attack.

Around 1.10am this morning (31 January) Police were called to a Centre Street address.

The two gunshot victims, a 17 year old female and a 16 year old male were both flown to Dunedin Hospital.

The female remains in a serious condition while the male is in a critical condition.

Southland Area Commander Inspector Mike Bowman says while the Police investigation is in its early stages, this is almost certainly an isolated occurrence.

"We want to reassure the community that this appears to be a targeted attack.

"Our team is working hard to establish what has happened, and our priority is to identify those responsible as soon as we can and hold them to account."

A scene examination is continuing and Police inquiries are ongoing.

Victim Support is working with members of the victims' families.

Anyone with information that may help Police is asked to contact them on 105 and refer to file number 220131/9471, or call Crime Stoppers anonymously on 0800 555 111.